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Organization >> Schleswig-Holstein University Hospital (UK-SH), Campus Kiel >>

Department of General Surgery and Thoracic Surgery

	2008 Anti-apoptotic and growth-stimmulatory functions of CK1 delta and epsilon in ductal Adeno carcionoma of the pancreas are inhibited by IC261 in vitro an in vivo Anti-Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo Dexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
	2007 Antitumor activity of ALK1 in pancreatic carcinoma cells Crnogorac-Jurcevic, T., N. R. Lemoine. 2007. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta(4) integrin and the PI3k pathway Detection of tumor stem cell markers in pancreatic carcinoma cell lines Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells Superiority of Extended Neoadjuvant Chemotherapy with Gemcitabine in Pancreatic Cancer
	2006 A modified random oligonucleotide-based combination therapy for adjuvant treatment of pancreatic ductal adenocarcinoma Adjuvant treatment of pancreatic carcinoma in a clinically adapted mouse resection model Combination phenylbutyrate/gemcitabine therapy effectively inhibits in vitro and in vivo growth of NSCLC by intrinsic apoptotic pathways Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells Stable expression of temperature-sensitive p53: a suitable model to study wild-type p53 function in pancreatic carcinoma cells TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
	2005 . Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase . Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression CD95 and TRAF2 promote invasiveness of pancreatic cancer cells Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival Gemcitabine-mediated apoptosis is associated with increased CD95 surface expression but is not inhibited by DN-FADD in Colo357 pancreatic cancer cells Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes Paraneoplastic leukemoid reaction and rapid progression in a patient with malignant melanoma: establishment of KT293, a novel G-CSF-secreting melanoma Significant growth inhibition of orthotopic pancreatic ductal adenocarcinoma by Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta
	2004 ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation Detection of occult tumor cells in lymph nodes from bladder cancer patients by MUC7 nested RT-PCR Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma Resistance developing after long-term ganciclovir prodrug treatment in apreclinical model of NSCLC Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis Terminally modified oligodeoxynucleotides directed against p53 in an orthotopic xenograft model: a novel adjuvant treatment strategy for pancreatic ductal carcinoma Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta



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