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Biochemisches Institut

	2021 ADAM17 Deficiency Protects against Pulmonary Emphysema. ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer Blocking only the bad side of IL-6 in inflammation and cancer Cathepsin D variants associated with neurodegenerative diseases show dysregulated functionality and modified α-synuclein degradation properties Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease. Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 Identification of the factor XII contact activation site enables sensitive coagulation diagnostics Initiation of Pancreatic Cancer: The Interplay of Hyperglycemia and Macrophages Promotes the Acquisition of Malignancy-Associated Properties in Pancreatic Ductal Epithelial Cells Interleukin-6 controls recycling and degradation, but not internalization of its receptors Interleukin-6: obstacles to targeting a complex cytokine in critical illness Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA Overlapping but Distinct Biological Effects of IL-6 Classic and Trans-Signaling in Vascular Endothelial Cells The endosome as signalling platform for IL-6 family cytokines The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis The two facets of gp130 signalling in liver tumorigenesis Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease Therapeutic targeting of IL-6 trans-signaling Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
	2020 A variant in IL6ST with a selective IL-11 signaling defect in human and mouse ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro Degradome of soluble ADAM10 and ADAM17 metalloproteases Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN. Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles Letter to the Editor: Non-specific effects resulting from use of tocilizumab in mice Necroptosis, ADAM proteases and intestinal (dys)function Repopulating microglia promote brain repair in an IL-6-dependent manner Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumor development and correlates with poor prognosis The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
	2019 Activated gp130 signaling selectively targets B cell differentiation to promote transformation of mature lymphoma and plasmacytoma ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury ADAM17: An Emerging Therapeutic Target for Lung Cancer Correction to: A new multiple trauma model of the mouse Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. Functional characterization of colon cancer-associated mutations in ADAM17: modifications in the pro-domain interfere with trafficking and maturation IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease Impaired mechanical, heat and cold nociception in a murine model of genetic TACE/ADAM17 knockdown Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3 Regulation of Fibrotic Processes in the Liver by ADAM Proteases The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes mellitus The synthetic retinoid acitretin increases IL-6 in the central nervous system of Alzheimer disease model mice and human patients Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage Treatment of type 2 diabetes and muscle atrophy with the designer cytokine IC7Fc
	2018 ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease. Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells. Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice. Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer. Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling Interleukin 6 trans-signalling and risk of future cardiovascular events. Interleukin-6 Family Cytokines. Interleukin-6: designing specific therapeutics for a complex cytokine. Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis. Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice. Pharmacologic IL-6R alpha inhibition in cholangiocarcinoma promotes cancer cell growth and survival. Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma. Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells. The ADAM17 Metalloproteinase Maintains Arterial Elasticity. The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
	2017 A new multiple trauma model of the mouse. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro. Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis. Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling. IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice IL6-Dependent Genomic Instability Heralds Accelerated Carcinogenesis Following Liver Regeneration on a Background of Chronic Hepatitis. Instructive role of the microenvironment in preventing renal fibrosis Interleukin 6 trans-signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole-induced seizures in mice. Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2 Meprin Metalloproteases shed and release soluble Interleukin-6 Receptor for trans-signaling Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib. Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice. Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation Proteolytic steps within signaling cascades make these signaling pathways irreversible. Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis. The Balance between Treg and TH17 cells: CD11b and Interleukin-6 The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. The role of ADAM17 in the T-cell response against bacterial pathogens. The role of IL-6 in host defence against infections: immunobiology and clinical implications. The shedding protease ADAM17: Physiology and pathophysiology. The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
	2016 A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing. ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses. ADAM17 substrate release in proximal tubule drives kidney fibrosis. ADAM17—HB-EGF—ErbB-mediated tonic brain blood flow control is suppressed in CADASIL small vessel disease Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer. Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source. Cellular Senescence Drives Radiation-Induced Loss of Salivary Gland Function and Is Prevented by Modulation of IL-6. Circulating soluble IL-6R but not ADAM17 activation drives mononuclear cell migration into the inflamed area Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17. Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling. Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia. IL-6 pathway in the liver: From physiopathology to therapy. IL-6 Trans-Signaling Drives Murine Crescentic GN. IL-6 trans-signaling is essential for the development of hepatocellular carcinoma. IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis. Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts. Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus. Interleukin-6 trans-signalling modulates Kras-induced lung carcinogenesis KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics. Novel Potent Proline-based Metalloproteinase Inhibitors: Design, (Radio)Synthesis and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts. Proteolytic Cleavage Governs Interleukin-11 Trans-signaling. Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation. The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. The role of interleukin-6 signaling in nervous tissue. Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema
	2015 "Family reunion" - A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat. ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis. Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis. Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome. IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans. Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN. Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer. Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells. Interleukin-6: Biology, signaling and strategies of blockade. Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture. Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome. RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity. Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. The soluble interleukin-6 receptor and related proteins Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex. Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma.
	2014 "Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells. 17alpha-hydroxylase deficiency diagnosed in early infancy caused by a novel mutation of the CYP17A1 gene A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor. A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10 Characterisation of three novel CYP11B1 mutations in classic and non-classic 11β-hydroxylase deficiency Characterization and function of the first antibiotic isolated from a vent organism: the extremophile metazoan Alvinella pompejana. Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations. Dendritic cell development requires histone deacetylase activity. Determination of disulfide linkages in antimicrobial peptides of the macin family by combination of top-down and bottom-up proteomics. Devic disease: translational medicine at work. Differential aggregation properties of alpha-synuclein isoforms. Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6 Glycoprotein 130 receptor signaling mediates a-cell dysfunction in a rodent model of type 2 diabetes. GP130 activation induces myeloma and collaborates with MYC. IL-6 biology: implications for clinical targeting in rheumatic disease. IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function. In vitro effectiveness of the antimicrobial peptide eCATH1 against antibiotic-resistant bacterial pathogens of horses Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Interleukin-6 and its receptors: a highly regulated and dynamic system. Interleukin-6: a villain in the drama of pancreatic cancer development and progression. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. LC-MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries. Mapping orphan proteases by proteomics: Meprin metalloproteases deciphered as potential therapeutic targets. Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency. Oncogenic deletion mutants of gp130 signal from intracellular compartments. Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130. Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor alpha ectodomain shedding. Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6. Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding. Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine. Stabilized Interleukin-6 receptor binding RNA aptamers. T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding. The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR). The biology of interleukin-6 in the 21st century. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
	2013 A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3). ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. ADAM17, shedding, TACE as therapeutic targets. ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates. An analysis of the function and expression of D6 on lymphatic endothelial cells. An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer. Cellular senescence and EGFR-signaling induce (IL-)6-receptor expression controlled by mammalian target of rapamycin (mTOR). d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers. Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice. gp130 activation is regulated by D2-D3 interdomain connectivity. Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells. Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength. Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions. mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets. Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction. Short-term TNFa shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17. The metalloproteases meprin alpha and meprin beta unique enzymes in inflammation, neurodegeneration, cancer and fibrosis. The regenerative activity of interleukin-6. The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin _ and ADAM10. TNFa cleavage beyond TACE/ADAM17: Matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis. Trp53 deficiency protects against acute intestinal inflammation.
	2012 A designer Hyper interleukin 11 (H11) is a biologically active supercytokine A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling Dendritic cell lineage commitment is instructed by distinct cytokine signals Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice Hitting a complex target: an update on interleukin-6 transsignalling IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling Interleukin-6 in sepsis and capillary leakage syndrome Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection Meprin alpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action Plasticity and cross-talk of interleukin 6-type cytokines Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from ES Cells Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane. The interleukin 6 pathway and atherosclerosis The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets. The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling Therapeutic Blockade of Interleukin-6 in Chronic Inflammatory Disease Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections. Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
	2011 A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, ADAM17: a molecular switch to control inflammation and tissue regeneration Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages Antimicrobial peptides and proteins of the horse - insights into a well-armed organism Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis Early Hepatocyte DNA Synthetic Response Posthepatectomy is Dependent on IL-6 Trans-Signaling and PI3K/AKT Activation ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Enhanced activity of meprin-alpha, a pro-migratory and pro-angiogenic protease, in colorectal cancer. Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer IL-6 trans-signaling licenses murine and human tumor microvascular gateways for trafficking of cytotoxic T cells IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 Inhibition of classic signaling is a novel function of soluble GP130 which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli. Selective blockade of IL-6 trans-signaling improves survival in a murine polymicrobial sepsis model Species specificity of ADAM10 and ADAM17 in IL-6 transsignaling and novel role of ADAM10 in inducible IL-6R shedding Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer Statins potently reduce the cytokine-mediated IL-6 release in SMC / MNC cocultures The pro- and anti-inflammatory properties of the Cytokine Interleukin-6 The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling Tumor growth in murine ulcerative colitis depends on innate signaling of colonic F4/80+ CD11bhigh Gr1 low macrophages Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization
	2010 A role for IL-27p28 as an antagonist of gp130-mediated signaling Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Allergen IgE-isotype-specific suppression by maternally derived monoclonal anti-IgG-idiotype Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans. Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity. Congenital lipoid adrenal hyperplasia: functional characterization of three novel mutations in the STAR gene. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application. Essential Role of Neutrophil Mobilization in Concanavalin A-Induced Hepatitis is based on Classic IL-6 Signaling but not IL-6 Trans-Signaling Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Human {beta}-defensin2 and {beta}-defensin3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models Insights into membrane association of Klebsiella pneumoniae NifL under nitrogen fixing conditions by mutational analysis Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production. Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases? J Cell Mol Med. Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. Processing of procollagen III by meprins: new players in extracellular matrix assembly? Role of IL-6 trans-signaling in CCl₄ induced liver damage Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. The Notch signaling pathway: Molecular basis of cell context dependency. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
	2009 A key role for gp130 expressed on peripheral sensory nerves in pathological pain. Antimicrobial activity of bovine psoriasin. Antimicrobial properties of the equine a-defensin DEFA1 against pathogenic bacteria of the horse Cell-free synthesis and combinatorial selective 15N labeling of the cytotoxic protein amoebapore A from Entamoeba histolytica Congenital adrenal hyperplasia due to 11-hydroxylase deficiency – insights from two novel CYP11B1 mutations (p.M92X, p.R453Q) Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep. Functional characterization of three CYP21A2 sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. Hydramacin-1, structure and antibacterial activity of a protein from the Basal metazoan hydra. IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. IL-6-trans-signalling increases rapid-eye-movement sleep in rats. Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice. Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances interleukin-6 and MCP-1 production. Interleukin-6 and Neural Stem Cells - More Than Gliogenesis. Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. Interleukin-6 Trans-Signaling Regulates Glycogen Consumption After d-Galactosamine-Induced Liver Damage. Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae. News from an ancient world: two novel astacin metalloproteases from the horseshoe crab. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels. Significance of loop structure and arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes. Steroid 17-Hydroxylase Deficiency: Functional Characterization of Four Mutations (A174E, V178D, R440C, L465P) in the CYP17A1 Gene Strategy of topical vaccination with nanoparticles. The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Transglutaminase-1 and bathing suit ichthyosis: molecular analysis of gene/environment interactions. Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity. Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Understanding receptor independent gp130 activation of viral interleukin-6.
	2008 A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia. An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis. Biochemical and functional characterization of anti-HIV antibody ELP fusion proteins from transgenic plants. Carboxyterminal mutations in 3beta-hydroxysteroid dehydrogenase cause congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase deficiency Functional and structural consequences of a novel point mutation in the CYP21A2 gene causing Congenital Adrenal Hyperplasia: Potential relevance of helix C for POR-CYP21 interaction IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts. IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. IL-6/IL-6R axis plays a critical role in acute kidney injury. IL6/sIL6R complex amplifies emergency granulopoietic response in the absence of G-CSF and GM-CSF. Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis. NMR analysis of viral protein structures. Notch signaling in embryonic and adult myelopoiesis. Notch1 activation reduces proliferation in the mulitpotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53. Reaction Mechanism and structural model of ADP-forming acetyl-CoA synthease from the hyperthermophilic archaeon pyrococcus furiosus: Evidence for a second active site histidine residue Stem cells, tissue regeneration and repair. Preface. Structure and mode of action of the antimicrobial peptide arenicin Structure guided optimization of the IL-6 transsignaling antagonist sgp130Fc. Synthetic Mimetics of the gp130-Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6 - gp130 Interaction. The transcription factor repertoire of Flt3+ hematopoietic stem cells. The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms. The transcription factor Interferon regulatory factor-4 controls experimental colitis via T cell derived interleukin-6. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. TLR-ligand induced podosome disassembly is ADAM17 dependent in dendritic cells and is accompanied by transient loss of migratory capacity. Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation.
	2007 A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function. Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils. CD30 targeting of lymphoma cells is misdirected by ADAM10-dependent antigen migration to CD30 ligand-expressing non-target cells. Classical IL-6 receptor signaling and IL-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac STAT3 activation and vascular hypertrophy in vivo. Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by Fever-range thermal stress. Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells. Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus. Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Interleukin-6 Trans Signaling Enhances Photodynamic Therapy by Modulating Cell Cycling Interleukin-31 and Oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. Local blockade of IL-6 receptor signaling induces lung CD4+ T cell apoptosis in a murine model of asthma. MMP-9-hemopexin domain hampers adhesion and migration of colorectal cancer cells. mNotch1 signaling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate beta-globin. Opposing Roles of gp130-Mediated STAT-3 and ERK-1/ 2 Signaling in Liver Progenitor Cell Migration and Proliferation. Proteins involved in sterol synthesis interact with Ste20 and regulate cell polarity. Self-Assembly of the isolated KCNQ2 subunit interaction domain Sequential processing of the transmembrane Chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.
	2006 Abrogation of vIL-6 induced signaling by intracellular retention and neutralization of vIL-6 with an anti vIL-6 single chain antibody selected by phage display. Acitvated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Baculovirus expression and functional characterisation of a recombinant human soluble gp130 isoform and its role in the regulation of L-6 trans-signaling. Ciliary neurotrophic factor reverses obesity-induced insulin resistance by activating skeletal muscle AMPK Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells. Elucidating the underlying molecular pathogenesis of NR3C2 mutantscausing autosomal dominant pseudohypoaldosteronism type 1. Fever-Range Thermal Stress Promotes Lymphocyte Trafficking Across High Endothelial Venules Through an IL-6 Trans-Signaling Mechanism. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells Forcing single-chain variable fragment production in tobacco seeds by fusion to elastin-like polypeptides. Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia (CAH): identification, functional characterization and structural analysis. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. gp130 Dimerization in the Absence of Ligand: preformed Cytokine Receptor Complexes Inhibition of hepatic fibrogenesis by MMP-9 mutants in mice Innovative liposomes as a transfollicular drug delivery system: penetration into porcine hair follicles. Interleukin-6 and its receptor: from bench to bedside. Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer. Interleukin-6 Trans-signaling in Inflammatory Bowel Disease: Potential Therapeutic Implication of Soluble GP130. Lipid-specific membrane activity of human b-defensin-3 Multilevel regulation of IL-6R by IL-6/sIL-6R fusion protein according to the primitiveness of the peripheral blood-derived CD133+ cells Sleep enhances IL-6 trans-signaling in humans Soluble IL15Ra sushi as a selective and potent agonist of IL-15 action through IL-15Rb/g hyperagonist IL-15-IL15Ra fusion proteins STAT3 activation via interleukin-6 trans-signaling contributes to ileitis in SAMP1/Yit mice Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19 The functional expression of a biologically active fragment of soluble gp130 as an ELP fusion protein in transgenic plants: purification via inverse-transition-cycling The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1. The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor. The structure of the IL-15a-receptor and its implications for ligand binding
	2005 A novel point mutation (E351K) in the ERR triad of the 21-hydroxylase leads to severe but not complete loss of CYP21 enzyme activity Ancient weapons: the three-dimensional structure of amoebapore Congenital adrenal hyperplasia (CAH) due to 11-hydroxylase deficiency: Functional characterization of two novel point mutations and a three base pair deletion in the CYP11B1 gene. Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Functional characterization of two novel point mutations in the CYP21 gene, as a cause of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency Functional interaction of a novel poly(ADP-ribose) polymerase with c-Myc IL-6 trans-signaling: the in vivo consequences. IL-6-induced potentiation of Iheat in rat sensory neurons: involvement of the soluble IL-6 receptor, Janus kinases and protein kinase C. Inhibition of TH2 cell survival and induction of regulatory T cells in the lung by local blockade of IL-6 signaling in a murine model of asthma L1 is sequentially processed by two differently activatedmetalloproteases and presenilin/g-secretase regulating neural celladhesion, cell migration and neurite outgrowth. Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus. No inhibition of IL-27 signaling by soluble gp130. Progressive and controlled development of mouse dendritic cells from Flt3+ CD11b+ progenitors in vitro. Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-b1. The Interleukin-6/gp130/STAT3 pathway in hepatocytes triggers liver protection in T-cell mediated liver injury. Viral IL-6 blocks neutrophil infiltration during acute inflammation.
	2004 1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor 1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor. Ataxin-10, the SCA10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. Development of a monoclonal-antibody-based enzyme linked immunoabsorbent assay for the IL-6/IL-6R interaction and its competitive inhibition. Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy. Essential role for mitochondrial thioredoxin reductase, a gene product of the del22q11 locus, in hematopoiesis, heart development and proper heart function. Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells. Growth factor deprivation-induced, but not Fas-induced, apoptosis is inhibited in uveitis: Role of IL-6/sIL-6R complexes. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen presenting cells.. Identification of an Interleukin-15a Receptor-binding Site on Human Interleukin-15 IL-6 trans-signaling: The heat is on. Maintenance of pluripotency in human embryonic stem cells is Stat3 independent. Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) Purification of spider silk-elastin from transgenic plants and application for human chondrocyte proliferation. Solution Structure of the Pore-forming Protein of Entamoeba histolytica T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals TGF-ß suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. The Interleukin-6 binding epitope of the third extracellular domain of the Interleukin-6 receptor revealed by NMR spectrocopy The interleukin-6 cytokine system regulates epidermal permeability barrier repair in wild-type and IL-6-deficient mice. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
	2003 Alteration of the Substrate Specificity of Benzoylformate Decarboxylase from Ps. putida by Directed Evolution Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). Characterization of a potent human interleukin-11 agonist Dentritic cells under influence of cytomegalovirus have a physiological dual role: to initiate and to restrict T cell acitvation. Differences in the Activation Mechanism between the alpha and beta Subunits of Human Meprin. Functional assignment of subdomains of the leukaemia inhibitory factor receptor to individual receptor binding epitopes of the ligand Interleukin-6 Biology is Coordinated by Membrane Bound and Soluble Receptors. Interplay between IFN-g and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. Notch signalling induces multilineage myeloid differentiation and upregulates PU.1 expression. Receptor engagement of Interleukin-6 type cytokines. Recombination signal sequence binding protein Jk alters mesodermal cell fate decision by suppressing cardiomyogenesis. Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction. Signalling of human CNTF revisited: the interleukin-6 (IL-6) receptor can serve as an a-receptor for ciliary neurotrophic factor (CNTF). Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130. Structural basis of calcium binding by a2-HS glycoprotein/ fetuin-A: formation of colloidal calciprotein particles The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion The Full Activation of the Protein Kinase DYRK1A Requires both Tyrosine Autophosphorylation and an Unusual Glutamine in the Activation Loop, The human interleukin–6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. The transient expression of PU.1 commits multipotent progenitors to a myeloid fate, while continued expression favours macrophage over granulocyte differentiation. Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling. Trans-sialidase from Trypanosoma congolense conserves most of the critical active site residues found in other trans-sialidases, Transcriptional Profiling Identifies Id2 function in dendritic cell development.
	2002 Cytokines as therapeutic drugs. Cytokines come of age. Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. Determination of donor-type chimerism using a semi-quantitative PCR-based method in a canine model for bone marrow transplantation. Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor. Full-lenght Complementary DNA and the Derived Amino Acid Sequence of Horse Uteroglobin, GP130 stimulation and the maintenance of stem cells. Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells. Improving the carboligase activity of benzoylformate decarboxylase from Pseudomonas putida by a combination of directed evolution and site-directed mutagenesis Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Molecular mechanisms of cytokine receptor activation Murine stromal cells producing hyper-interleukin-6 and Flt3 ligand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors. Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12. The Effect of gp130 Stimulation on Glutamate-induced excitotoxicity in Primary Hippocampal Neurons. The MMP-9 hemopexin domain is a novel gelatin binding domain and acts as an antagonist. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex.
	2001 A bioinformatical approach reveals the function of the autoimmune hepatitis target antigen SLA / LP. A novel and rapid prediction assay for the effectiveness of IL-6 receptor specific antisense oligonucleotides by proliferation inhibition of an interleukin-6 dependent cell line. Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment. Coordination of interleukin-6 biology by membrane bound and soluble receptors. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells. gp130-Stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells. Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor. Hyper-IL-6 Gene Therapy Reverses Fulminant Hepatic Failure. Identification of the autophosphorylation sites and characterization of their effects in the dual-specificity protein kinase DYRK1A. Identification of the domain in the Interleukin-11 Receptor that mediates ligand binding IL-6 and soluble IL-6R induce stem cell factor (SCF) and Flt-3 ligand expression in vivo and in vitro. In vitro reconstitution of recognition and activation complexes of Interleukin-6 signaling machinery. Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the Trimera mouse model of chronic HBV infection. Mapping of a region within the N-terminus of JAK1 involved in cytokine receptor interaction. Possible Role Of Human Interleukin-6 And Soluble Interleukin-6-Receptor In Hepatitis B Virus Infection. Production of spider silk proteins in tobacco and potato. Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins. Signals regulating neurotrophin expression in glial cells. Soluble gp130 is the natural inhibitor of soluble il-6r transsignaling responses. Structure of an extracellular gp130 cytokine receptor signalling complex. Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I Systemic inhibition of spontaneous calcification by the serum protein a2-HS glycoprotein/fetuin. The Designer Cytokine Hyper-IL-6 Mediates Growth Inhibition and GM-CSF-Dependent Rejection of B16 Melanoma Cells. The signal transducer gp130: Biochemical characterization of the three membrane-proximal extracellular domains and studies on their oligomerization potential. Transcription of mutS- and mutL-homologous genes during meiosis in Saccharomyces cerevisiae and identification of a regulatory cis-element for meiotic induction of MSH2. Up- and down-regulation of granulocyte-macrophage colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
	2000 A MMP-9 mutant without gelatinolytic activity abrogates TIMP-1 associated migration pattern An IL-6/IL-6 soluble receptor (IL-6R) hybrid protein (H-IL-6) induces Epo-independent erythroid differentiation in human CD34+ cells. Astrocytic Alterations in Interleukin-6/soluble Interleukin-6 Receptor a Double-Transgenic Mice. Benzoylformate decarboxylase from Pseudomonas putida as stable catalyst for the synthesis of chiral 2-hydroxy ketones Blockade of IL-6 trans-signaling abrogates established experimental colitis in mice by suppression of T cell resistance against apoptosis. Characterization of the new mutator gene Mph1 of Saccharomyces cerevisiae. Combined Interleukin-6 and soluble Interleukin-6 Receptor accelerates murine liver regeneration. Contribution of the Amino Acid Sequence at the Cleavage Site to the Cleavage Pattern of Transmembrane Proteins. Different requirements for the activation of gp130 in homo- versus heterodimeric receptor complexes Donor stromal cells from human blood engraft in NOD/SCID mice. Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin. Enzymatically degraded, non-oxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation and proliferation. Generation of functionally mature dendritic cells from the multipotential stem cell line FDCP-mix. Generation of Human Cytotoxic T Lymphocytes against the Tumor-Associated Antigen HER2 using Retrovirally Transduced Dendritic Cells Derived from CD34+ Hematopoietic Progenitor Cells. Genetically modified tumour vaccines (GMTV) in melanoma clinical trials. Herpesvirus Type 8 Interleukin-6 Homologue triggers gp130 on and neuronal and hematopoietic cells Euro. Human Herpesvirus 8 Interleukin-6 Homologue triggers gp130 on neuronal and hematopoietic cells. Human Interleukin-6 facilitates hepatitis B virus infection in vitro and in vivo. IL-6-Receptor independent stimulation of human gp130 by viral IL-6. Insertional mutagenesis as a route to identifying genes involved in self renewal of haemopoietic stem cells. Liver Regeneration induced by a designed hIL-6/shIL-6R fusion protein -reverses severe hepatocellular injury. mNotch1 signalling reduces proliferation of myeloid progenitor cells ba altering cell cycle kinetics. Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Ra) and their use in studies of human mononuclear cells New Perspectives in the Design of Cytokines and Growth Factors. Notch signalling via RBP-J promotes myeloid differentiation Soluble Interleukin-6 Receptor (sIL-6R) makes IL-6R Negative T Cell Line Respond to IL-6; It Inhibits TNF Production. The gp130 stimulating designer cytokine Hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells. The Importance of Shedding of Membrane Proteins for Cytokine Biology. Two different epitopes of the signaltransducer gp130 sequentially cooperate upon interleukin-6-induced receptor activation
	1999 A fusion Protein of IL-11 and soluble IL-11 receptor acts as a superantagonist on cells expressing gp130 A role for the Immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding. Activation of the signal transducer gp130 by both interleukin-6 and interleukin-11 requires two distinct binding epitopes Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain Definition of receptor binding sites on human interleukin-11 by molecular modelling-guided mutagenesis Euro. Expression of glypican-4 in haematopoietic progenitor and bone marrow stromal cells. Generation and Function of the Soluble Interleukin-6-Receptor. gp130-signaling synergizes with FL and TPO for the long-term expansion of cord blood progenitors. Heparan sulphate proteoglycan expression is induced during early erythroid differentiation of multipotent hematopoietic stem cells. HLA Class II restriction of autoreactive T cell responses in pemphigus vulgaris: Review of the literature and potential applications for the development of a specific immunotherapy IL-6 dependent biology and therapy: where do we stand and what are the options?. IL-6 type Cytokine Receptor Complexes: Hexamer or Tetramer or Both? Immunoadhesins of IL-6 and Hyper-IL-6. Interleukin-6 (IL-6) Supports Survival of Sensory Neurons: Autocrine Trophic Effects of IL-6 and Soluble IL-6 Receptor and Enhanced Activity of an IL-6 Designer Cytokine. Introduction to stem cell biology in vitro: threshold to the future. Neuronal Activities of IL-6 Type Cytokines often Depend on Soluble Cytokine Receptors. Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. Optimization of Retroviral-mediated Gene Transfer to Human NOD/SCID mouse Repopulating Cord Blood Cells through a systematic Analysis of protocol variables. Rapid Differentiation of a rare subset of adult Human Lin-Cd34-Cd38- Cells Stimulated by multiple Growth Factors in vitro. Receptor recognition sites of cytokines are organized as exchangeable moduls: transfer of the LIFR binding site from CNTF to IL-6. Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression. TGFß1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. The designer cytokine H-IL-6 is a potent activator of STAT3-dependent gene transcripton in vivo and in vitro. The IL-6/sIL-6R fusion protein promotes neurite outgrowth and neuronal survival in cultured enteric neurons. The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region The solution structure of a superpotent B-chain-shortend single-replacement insulin analogue
	1998 A new type of Cytokine Receptor Antagonist directly targeting gp130. Active site mutants of pyruvate decarboxylase from Zymomonas mobilis. A site directed mutagenesis study of L112, I472, I476, E473 and N482. Euro. Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extramedullary Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice. Immunogene therapy of human melanoma. Phase I/II clinical trial. . In vivo and in vitro Activity of the gp130 Stimulating Designer Cytokine Hyper-IL-6. Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis. More about genetically modified tumour vaccines. Oncostatin M, leukemia inhibitory factor and interleukin-6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells. Recombinant Human scFv Antibodies Recognizing Human Interleukin-6: Specific Targeting of Cytokine Secreting Cells. Regulation of the Type II OSM Receptor Expression in human lung-derived epithelial cells Role of IL-6 and the Soluble IL-6 Receptor in Inhibition of VCAM-1 Gene Expression. Soluble Interleukin 6 (IL-6) Receptor influences the expression of the protooncogene junB and the production of fibrinogen in the HepG2 Human Hepatoma cell line and primary rat hepatocytes. Specific Targeting of Cytokine Secreting Cells: A Bispecific Diabody Recognizing human IL-6 and CD3 induces T-cell Mediated Killing. Sympathetic Neurons can produce and respond to Interleukin-6. The Interleukin-11/Receptor Complex: Rational Design of Agonists/Antagonists and Immunpassys Potentially useful in Human Therapy Res. The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6-Receptor is Sufficient for Ligand Binding but not for gp130 Association.
	1997 A Bioactive Designer Cytokine For Human Hematopoietic Progenitor Cell Expansion. Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy. Analysis of the hIL-6/hIL-6-R binding interface at the amino acid level. Proposed mechansim of interaction Analysis of the mechanism of action of anti-human interleukin-6 (hIL-6) and anti-hIL-6 receptor neutralising monoclonal antibodys Euro. Exclusion of bioactive contaminations in Streptococcus pyogenes erythrogenic toxin A (SPEA) preparations by recombinant expression in Escherichia coli Infect. Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice. IL-6 Receptor-IL-6 Fusion Proteins with enhanced IL-6 Type pleiotropic activities. Inactive conformation of an insulin despite its wild-type sequence Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer’s disease patients. Molecular modeling guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the IL-6/IL-6-receptor/gp130 complex Oncostatin M stimulates the expression and release of the IL-6 Receptor in Human Hepatoma HepG2 Cells. Proteoglycan synthesis in haematopoietic cells - Isolation and characterization of proteoglycans from the bone marrow stromal cell line MS-5. Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells. Soluble IL-6 Receptor leads to a paracrine modulation of the hepatic acute phase response in double transgenic mice. The family of the IL-6-type cytokines: Specificity and Promiscuity of the Receptor Complexes. The role of soluble growth factors in inducing transient growth and clonal extinction and of stroma-cell dependent erythroblastic leukemia cells. The signal transducer gp130: Bacterial expression, refolding and properties of the carboxy-terminal domain of the cytokine-binding module Euro. The Therapeutic Potential of Interleukin-6 Hyperagonists and Antagonists. Three different putative Phosphate Transport receptors are present encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG TIMP expression in toxic and cholestatic liver injury in rat.
	1996 A convenient assay for different species of cytokines and soluble receptors of the IL-6 type cytokine family. APRF/STAT3, Increased binding and Target Gene Activation during Liver regeneration. Biosynthesis and distribution of leucocyte elstase inhibitor. Production of recombinant inhibitor. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts. Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding Fibroblasts retrovirally transfected with the human IL-3 gene initiate and sustain multilineage human hematopoiesis in SCID mice: comparison of CD34-enriched vs. CD34-enriched and in vitro expanded grafts. High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors. Identification of residues in the putative 5th-helical region of human interleukin-6, important for activation of the IL-6 signal transducer gp130. Identification of single amino acid residues of human Interleukin-6 involved in receptor binding and signal initiation. Novel Pathogenic Mechanism of Microbial Metalloproteinases: Liberation of Membrane-Anchored Molecules in Biologically Active Form Exemplified by Studies with the Human IL-6 Receptor. Participation of two Ser-Ser-Phe-Tyr motifs in the ligand binding site of human interleukin-6 receptor. Pore Forming Toxins Trigger Shedding of Receptors for Interleukin-6 and Lipopolysaccharide. Proteoglycan synthesis in human and murine multipotent haematopoietic cell lines - isolation and characterization of heparan sulfate proteoglycans as the major proteoglycans from the human haematopoietic cell line TF-1. Site directed mutagensis of conserved charged residues in the helical region of the human C5a receptor Euro. Solution structure of a mini IGF-1 Subline dependency of hydronephrosis in hybrid laboratory mice (DBA/2J x C57BI/6J) The function of the soluble IL-6 Receptor in vivo. The function of the soluble IL-6 Receptor: Human soluble IL-6 receptor transgenic mice are hypersensitized towards the IL-6-mediated acute phase response and show prolonged plasma half life of IL-6. Transcriptional regulation of the c-fms proto-oncogene mediated by granulocyte/macrophage colony-stimulating factor (GM-CSF) in murine cell lines. Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor Yeast Expression of the Cytokine Receptor Domain of the Soluble Interleukin-6-Receptor. Zytokine: Biologie und Therapeutische Relevanz.
	1995 A Metalloproteinase Inhibitor blocks shedding of the IL-6R and the p60 TNFR. A new Hepatocyte Stimulating Factor: Cardiotrophin-1 (CT-1). Combining two mutations that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells. Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Functional Analysis of Recombinant Human Ciliary Neurotrophic Factor Mutants. Functional distinction between regions of human interleukin-6 important for signal transduction via gp130. Gene therapy of human melanoma: immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin-6 and soluble interleukin-6 receptor. Human Ciliary Neurotrophic Factor (CNTF): A Structure-function analysis. Human CNTF and related Cytokines: Effects on DRG Neuron Survival. Leucine 58 in the putative 5th-helical region of Human Interleukin (IL)-6 is involved in IL-6 Receptor-a-chain-dependent binding of IL-6 to gp130. Models of G-protein coupled receptors revised for family wide compliance with experimental data. A new sequence accommodation suggested for helix G Residues 77-95 of the human interleukin-6 protein are responsible for receptor binding and residues 41-56 for signal transduction Soluble human interleukin-6 receptor. Soluble interleukin-6 receptor is biologically active in vivo. The Hox 2.4 gene is not involved in the generation of IL-3 dependent multipotential FDCP-mix cell lines. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. The replacement of tryptophan-392 by alanine influences the decarboxylase/carboligase activity and stability of pyruvate decarboxylase from Zymomonas mobilis Euro. The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: A xenotransplant model for huPBSC-initiated hematopoiesis. The soluble Interleukin-6 receptor Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver is increased by LPS and Prostaglandin E2.
	1994 Biosynthesis and Half-Life of the Interleukin-6 Receptor and its Signal Transducer gp130. Calculation of the circular dichroism spectrum of cyclo-(L-tyr-L-tyr) based on a molecular dynamics simulation Can the position of a conserved disulfide bridge be used to validate models of G-protein coupled receptors? Coordinate expression of the lineage-specific growth factor CFS-1 and its receptor selectively promotes macrophage maturation durin differentiation of mulitpotential progenitor cells. Development of a human interleukin-6 receptor antagonist. Development of an Interleukin-6 Receptor Antagonist that inhibits IL-6-Dependent Growth of Human Myeloma Cells. Identification of a region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. Identification of two novel regions of Human IL-6 responsible for receptor binding and signal transduction. Modelling of G-protein coupled receptors with bacteriorhodopsin as a template. A novel approach based on interaction energy differences Mutants of a mulitpotent haematopoietic cell line blocked in GM-CSF- Induced differentiation are leukemogenic in vivo. Reversible dissociation and unfolding of pyruvate decarboxylase from Zymomonas mobilis Euro. Selectable retroviral vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression. Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor Euro. Soluble Growth Factor and Cytokine Receptors: Generation and Biological Function. The Soluble Human Interleukin-6 Receptor: Mutational Characterization of the Proteolytic Cleavage Site. TIMP-1 protein expression is stimulated by IL-1ß and IL-6 in primary rat hepatocytes.
	1993 Cyclic Disulfide Analogues of the Complement Component C3a Determination of the three-dimensional solution structure of the histidine-containing phosphocarrier protein HPr from Escherichia coli using multidimensional NMR spectroscopy Euro. Intracellular Retention of Interleukin-6 abrogates signaling. Molecular cloning and expression of an intracellular serpin: Elastase inhibitor from horse leukocytes. Recombinant soluble human Interleukin-6 Receptor: Expression in Escherichia coli, renaturation and purification. Shedding of the Two Subunits of the Interleukin-6 Receptor. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules: involvement of two separate domains in receptor binding. Targeted in vivo infection with a retroviral vector carrying the Interleukin-3 (Mulit-CSF) gene leads to immortalization and leukemic transformation of primitive hematopoietic progenitor cells. The hepatic interleukin-6-receptor: Studies on its structure and regulation by Phorbol 12-myristate 13-acetate-Dexamethasone. The Histidin containing Protein HPr The human soluble Interleukin-6-Receptor is generated by shedding. The sequential assignment and secondary structure of the IIa domain from the E-coli mannitol transport system by heteronuclear three-dimensional NMR spectroscopy Upregulation of lineage specific receptors and ligands in mulitpotent progenitor cells is part of an endogenous program of differentiation.
	1992 Ciliary neurotrophic factor induces Acute Phase response in Hepatocytes. Interferon-g regulates a2-Macroglobulin and a1-antichymotrypsin expression on the pretranslational level in HepG2 cells. Protein Kinase C Activity is Rate Limiting for Shedding of the Interleukin-6 Receptor. Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of a1-protease inhibitor secreted by HepG2 cells. Synthesis of tissue inhibitor of metalloproteinases-1 (TIMP-1) in human hepatoma cells (HepG2): Up-regulation by interleukin-6 and transforming growth factor ß1. The complex of soluble human interleukin-6-receptor/interleukin-6 upregulates synthesis of acute-phase proteins. The hepatic interleukin-6-receptor: down-regulation of the interleukin-6-binding subunit (gp80) by its ligand. Up-regulation of the interleukin-6-signal transducing protein (gp 130) by interleukin-6 and dexamethasone in HepG2 cells.
	1991 A model for the C5a receptor and for its interaction with the ligand Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6. Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation. Retroviral vectors related to the myeloproliferative sarcoma virus allow efficient expression in hematopoietic stem and precursor cell lines, but retroviral infection is reduced in more primitive cells. Structural and functional studies on the human hepatic IL-6-receptor: Molecular cloning and overexpression in HepG2 cells. Structural and functional studies on the human interleukin-6-receptor: Binding, cross-linking, internalization and degradation of interleukin-6 by fibroblasts transfected with human IL-6-receptor-cDNA.
	1990 Conformationally restricted C3a analogues Microheterogeneity of human interleukin-6 synthesized by transfected NIH 3T3 cells: comparison with human monocytes, fibroblasts, and endothelial cells. Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function. Studies on the structure and regulation of the human hepatic interleukin-6-receptor. The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity.
	1989 Biological effects of retroviral transfection of the murine Interleukin-3 gene into FDCP-Mix cells. cDNA cloning sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I. Expression of the kinase domain of mouse protein kinase C in E.coli. Rates of mutation to growth factor autonomy and tumorigenicity differ in Hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.
	1988 Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of Phorbol Ester TPA in vivo and in vitro. Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements Differential effects of Phorbol esters on the expression of the ornithine decarboxylase gene and on c-myc and c-fos expression in mouse skin in vitro. Molecular cloning of mouse protein kinase C(PKC)cDNA from Swiss 3T3 fibroblasts.
	1987 An Evaluation of 2,5-norbornadiene as a reversible Inhibitor of ethylene action in Deepwater Rice. Enantiomeric Resolution of Amino Acid Derivatives on Chiral Stationary Phases by High-Performance Liquid Chromatography Myelo-monocytic differentiation potential of the cALLA-positive Nalm 6M1 cell line. The Induction of ODC by the tumor promoter TPA is controlled at the post-transcriptional level in murine Swiss 3T3 fibroblasts.
	1985 Short-term growth response of deep-water rice to submergence and ethylene.
	1984 Effect of submergence on the cell-wall composition of deep-water rice internodes.
	1983 Temperature dependent auxin efflux from moss protonema. The mechanism of auxin uptake and accumulation in moss protonemata. Uptake and polar transport of indolacetic acid in moss rhizoids.

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